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Document type:
Zeitschriftenartikel / Journal Article
Title:
Subdiffusion Supports Joining Of Correct Ends During Repair Of DNA Double-Strand Breaks
Journal:
Scientific Reports
Volume:
3
Year:
2013
Language:
Englisch
Keywords:
DNA ; MDC1 protein, human ; nuclear protein ; transactivator protein, article ; biological model ; chemistry ; chromatin ; diffusion ; DNA damage ; DNA repair ; genetics ; human ; osteosarcoma ; protein binding ; statistical model ; tumor cell line, Cell Line, Tumor ; Chromatin ; Diffusion ; DNA Damage ; DNA Repair ; DNA, Neoplasm ; Humans ; Models, Genetic ; Models, Statistical ; Nuclear Proteins ; Osteosarcoma ; Protein Binding ; Trans-Activators
Abstract:
The mobility of damaged chromatin regions in the nucleus may affect the probability of mis-repair. In this work, live-cell observation and distance tracking of GFP-tagged DNA damage response protein MDC1 was used to study the random-walk behaviour of chromatin domains containing radiation-induced DNA double-strand breaks (DSB). Our measurements indicate a subdiffusion-type random walk process with similar time dependence for isolated and clustered DSBs that were induced by 20 MeV proton or 43 Me... »
ISSN:
2045-2322
Article ID:
2511
DOI:
Department:
Fakultät für Luft- und Raumfahrttechnik
Institute:
LRT 2 - Institut für angewandte Physik und Messtechnik
Chair:
Dollinger, Günther
Open Access yes or no?:
Nein / No
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