Wank, Michaela; Schilling, Daniela; Reindl, Judith; Meyer, B.; Gempt, J.; Motov, S.; Alexander, F.; Wilkens, Jan J.; Schlegel, J.; Schmid, Thomas E.; Combs, Stephanie E.
Document type:
Zeitschriftenartikel / Journal Article
Title:
Evaluation of radiation-related invasion in primary patient-derived glioma cells and validation with established cell lines
Subtitle:
impact of different radiation qualities with differing LET
Journal:
Journal of Neuro-Oncology
Volume:
139
Issue:
3
Year:
2018
Pages from - to:
583-590
Language:
Englisch
Abstract:
Glioblastoma multiforme (GBM) is the most common primary brain tumor and has a very poor overall prognosis. Multimodal treatment is still inefficient and one main reason is the invasive nature of GBM cells, enabling the tumor cells to escape from the treatment area causing tumor progression. This experimental study describes the effect of low- and high-LET irradiation on the invasion of primary GBM cells with a validation in established cell systems.