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Autoren:
Lüders, Laura von; Tilmann, Rita; Lee, Kangho; Bartlam, Cian; Stimpel-Lindner, Tanja; Nevanen, Tarja K.; Iljin, Kristiina; Knirsch, Kathrin C.; Hirsch, Andreas; Duesberg, Georg S. 
Dokumenttyp:
Zeitschriftenartikel / Journal Article 
Titel:
Functionalisation of Graphene Sensor Surfaces for the Specific Detection of Biomarkers 
Zeitschrift:
Angewandte Chemie International Edition 
Jahrgang:
62 
Heftnummer:
22 
Jahr:
2023 
Seiten von - bis:
e202219024 
Sprache:
Englisch 
Stichwörter:
Antibody-Antigen System ; Biosensors ; Functional Layer Transfer ; Graphene ; Noncovalent Functionalization 
Abstract:
We report on a controllable and specific functionalisation route for graphene field‐effect transistors (GFETs) for the recognition of small physiologically active molecules. Key element is the noncovalent functionalisation of the graphene surface with perylene bisimide (PBI) molecules directly on the growth substrate. This Functional Layer Transfer enables the homogeneous self‐assembly of PBI molecules on graphene, onto which antibodies are subsequently immobilised. The sensor surface was characterised by atomic force microscopy, Raman spectroscopy and electrical measurements, showing superior performance over conventional functionalisation after transfer. Specific sensing of small molecules was realised by monitoring the electrical property changes of functionalised GFET devices upon the application of methamphetamine and cortisol. The concentration dependent electrical response of our sensors was determined down to a concentration of 300 ng ml-1 for methamphetamine. 
ISSN:
1433-7851 ; 1521-3773 
Article-ID:
e202219024 
Fakultät:
Fakultät für Elektrotechnik und Informationstechnik 
Institut:
EIT 2 - Institut für Physik 
Professur:
Düsberg, Georg S. 
Projekt:
Graphene Flagship Core 3; ACDC; VITAL-SENSE; DEAL 
Open Access ja oder nein?:
Ja / Yes 
Art der OA-Lizenz:
CC BY-NC-ND 4.0