Low LET proton microbeam to understand high-LET RBE by shaping spatial dose distribution
Titel Sammlung:
Proceedings of the 15th International Conference on Nuclear Microprobe Technology and Applications
Zeitschrift:
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
Jahrgang:
404
Heftnummer:
Supplement C
Konferenztitel:
International Conference on Nuclear Microprobe Technology and Applications (15., 2017, Lanzhou)
Tagungsort:
Lanzhou, China
Jahr der Konferenz:
2017
Datum Beginn der Konferenz:
31.07.2017
Datum Ende der Konferenz:
05.08.2017
Jahr:
2017
Seiten von - bis:
155-161
Sprache:
Englisch
Stichwörter:
Proton microbeam ; LET ; Spatial dose distribution ; RBE ; Fluorescent nuclear track detector
Abstract:
High LET radiation, like heavy ions, are known to have a higher biological effectiveness (RBE) compared to low LET radiation, like X- or -rays. Theories and models attribute these higher effectiveness mostly to their extremely inhomogeneous dose deposition, which is concentrated in only a few micron sized spots. At the ion microprobe SNAKE, low LET 20 MeV protons (LET in water of 2.6 keV/μm) can be applied to cells either randomly distributed or focused to submicron spots, approximating heavy ion dose deposition. Thus, the transition between low and high LET energy deposition is experimentally accessible and the effect of different spatial dose distributions can be analysed. Here, we report on the technical setup to cultivate and irradiate 104 cells with submicron spots of low LET protons to measure cell survival in unstained cells. In addition we have taken special care to characterise the beam spot of the 20 MeV proton microbeam with fluorescent nuclear track detectors. «
High LET radiation, like heavy ions, are known to have a higher biological effectiveness (RBE) compared to low LET radiation, like X- or -rays. Theories and models attribute these higher effectiveness mostly to their extremely inhomogeneous dose deposition, which is concentrated in only a few micron sized spots. At the ion microprobe SNAKE, low LET 20 MeV protons (LET in water of 2.6 keV/μm) can be applied to cells either randomly distributed or focused to submicron spots, approximating heavy io... »